Україна, Львів
+38 (050) 6956878

Closol Spray. 50ml

Closol Spray. 50ml


Broad-spectrum antifungal agent for external use



Each ml of solution contains:

Clotrimazole 10 mg

Auxiliary components:

Benzalkonium chloride, propylene glycol, cetosteryl alcohol, isopropyl alcohol.


Broad-spectrum antifungal agent for external use. The action of clotrimazole is associated with a violation of the synthesis of ergosterol, which is part of the cell membrane of fungi, which changes the permeability of the cytoplasmic membrane and causes subsequent cell lysis. At low concentrations, it acts fungistatically, at high concentrations it is fungicidal, and not only on proliferating cells. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in the concentration of hydrogen peroxide to a toxic level, which also contributes to the destruction of fungal cells.

Clotrimazole exhibits fungicidal and fungistatic activity against dermatomycetes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), yeast-like and mold fungi (Candida spp., including Candida albicans; Torulopsis glabrata, genus Rhodotorula, Pityrosporum orbiculare). Active against the causative agent of multi-colored lichen – Pityrosporum orbiculare (Malasseziafurfur). Effective against Gram-positive bacteria – the causative agent of erythrasma Corynebacterium minutissimum, as well as Staphylococcus spp., Streptococcus spp., Gram-negative bacteria – Bacteroides, Gardnerella vaginalis. In high concentrations, it is active against Trichomonas vaginalis.

Does not affect lactobacilli. Primarily resistant variants of susceptible fungi are very rare; the development of secondary resistance in susceptible fungi has also been noted in exceptional cases under therapeutic conditions.


fungal infections of the skin; interdigital fungal erosion; mycoses complicated by secondary infection; multi-colored lichen; erythrasma.

Dosage and administration:

It is applied externally to the affected areas of the skin 2 times a day, in the morning and in the evening. The course of treatment is up to 4 weeks.


Hypersensitivity to clotrimazole; I trimester of pregnancy.

Precautionary measures:

If allergic reactions or irritation occur at the site of application, the treatment is stopped.

To prevent reinfection, hygiene rules should be followed.

It is not recommended to apply clotrimazole to the skin in the eye area.

If clinical signs of infection persist after completion of treatment, a repeat microbiological examination should be performed to confirm the diagnosis.

Side effects:

From the immune system: allergic reactions, incl. urticaria, shortness of breath, arterial hypotension, fainting.

From the skin and subcutaneous tissues: rash, itching, blisters, peeling, pain / discomfort, swelling, burning, irritation, erythema, tingling.

Storage method:

At a temperature not higher than 30 degrees. In a dry place.


There are no reviews yet.

Be the first to review “Closol Spray. 50ml”

Your email address will not be published.