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Duphalac 667g/l 200ml

Duphalac 667g/l 200ml

269.00

Laxative

Description

Compound:

Lactulose 667 mg/ml

Auxiliary components:

citric acid, purified water

Properties:

Laxative. Lactulose, a disaccharide consisting of galactose and fructose, is not hydrolyzed by disaccharidases of the small intestine mucosa. It has a hyperosmotic laxative effect, stimulates intestinal motility, improves the absorption of phosphates and calcium salts, promotes the excretion of ammonium ions.

Lactulose is broken down by the intestinal flora of the large intestine into low molecular weight organic acids, which leads to a decrease in pH and an increase in osmotic pressure and, as a result, an increase in the volume of intestinal contents. These effects stimulate intestinal motility and affect the consistency of the stool. The physiological rhythm of emptying the large intestine is restored.

In hepatic encephalopathy, the effect is attributed to the suppression of proteolytic bacteria by increasing the number of acidophilic bacteria (eg, lactobacilli), the transition of ammonia to the ionic form due to acidification of the contents of the colon; bowel movements due to a decrease in pH in the colon and an osmotic effect; as well as reducing the content of nitrogen-containing toxic substances by stimulating bacteria that utilize ammonia for bacterial protein synthesis.

Lactulose as a prebiotic substance enhances the growth of beneficial bacteria such as bifidobacteria and lactobacilli, while it becomes possible to suppress the growth of potentially pathogenic bacteria such as Clostridium spp. and Escherichia coli, which provides a more favorable balance of intestinal flora.

Indications:

Chronic constipation, as well as diseases requiring relief from bowel movements. Prevention and treatment of hepatic encephalopathy in adults.

Dosage and administration:

Adults:

The usual initial (first three days) daily dose is 45 ml (3 tablespoons) of syrup taken once before breakfast or 15 ml (1 tablespoon) three times a day before meals. After achieving a therapeutic effect, a maintenance dose of 15 ml (1 tablespoon) of syrup should be taken on an empty stomach.

Children over 3 years old:

Initially 5 to 15 ml of syrup per day, the dose can be gradually increased every 3 days until the desired effect is achieved.

Children under 3 years old:

Initially 5 ml of syrup per day, the dose can be gradually increased every 3 days until a normal bowel movement is achieved.

Infants:

Initially 2.5 ml syrup per day, the dose can be gradually increased every 3 days until a normal bowel movement is achieved.

If abdominal distention occurs, reduce the dose to what is tolerated by the child.

Hepatic encephalopathy:

Adults: 20 ml to 80 ml of syrup per day in 3-4 divided doses.

Large doses of the drug used in the treatment of hepatic encephalopathy can cause diarrhea. The dose should be selected in such a way that the amount of liquid stool does not exceed 2-3 per day.

Before use, you can mix the drug with water, fruit juices or milk.

Contraindications:

Hypersensitivity to lactulose; intestinal obstruction; intolerance to fructose, galactose; lactase deficiency; glucose-galactose malabsorption; galactosemia; rectal bleeding (which is not caused by hemorrhoids); suspicion of appendicitis, acute inflammatory diseases of the abdominal cavity.

With caution: diabetes mellitus, colostomy or ileostomy.

Precautionary measures:

It should not be used for abdominal pain, nausea, vomiting without verification of the diagnosis.

It should not be used for inflammatory diseases of the gastrointestinal tract in the acute stage, as well as for violations of water and electrolyte metabolism.

Use with caution in patients with gastrocardiac syndrome. In such cases, treatment should be started at low doses and increased gradually to avoid flatulence.

Use with caution in patients with diabetes mellitus, especially in inflammatory lesions of the colon.

With long-term treatment (more than 6 months), the level of potassium, chlorine and carbon dioxide in the blood plasma should be regularly monitored.

During therapy with laxatives, it is recommended to take a sufficient amount of liquid (1.5-2 l / day, which corresponds to 6-8 glasses of 250 ml).

Side effects:

From the side of metabolism: very rarely – hypernatremia; the frequency is unknown – disorders of water and electrolyte metabolism that occur due to diarrhea.

From the digestive system: nausea, vomiting, abdominal pain, flatulence, diarrhea.

Storage method:

At a temperature not higher than 30 degrees. In a dry place.

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