Description

Compound: Each tablet contains:

Acetaminophen 250 mg

Aspirin 250 mg

Caffeine 65 mg

Auxiliary components: Hydroxypropyl cellulose, microcrystalline cellulose, stearic acid, povidone, propylene glycol, sorbital monolaurate, titanium dioxide.

Properties: Panadol Migraine is a combination drug containing acetaminophen (paracetamol), aspirin (acetylsalicylic acid) and caffeine. Paracetamol has an analgesic, antipyretic and extremely weak anti-inflammatory effect, which is associated with its effect on the thermoregulatory center in the hypothalamus and a weak ability to inhibit the synthesis of prostaglandins in peripheral tissues. Acetylsalicylic acid has analgesic, antipyretic and anti-inflammatory effects. It quickly relieves pain, especially caused by the inflammatory process, and also moderately inhibits platelet aggregation and slows down the process of thrombosis, improving microcirculation in the inflammation site. Caffeine increases the reflex excitability of the spinal cord, excites the respiratory and vasomotor centers, dilates the blood vessels of the skeletal muscles, brain, heart, kidneys, and reduces platelet aggregation. Reduces drowsiness, fatigue, increases mental and physical performance. In this combination, caffeine in a small dose has practically no stimulating effect on the central nervous system, but it helps to normalize the tone of cerebral vessels and accelerate blood flow in it.

Indications: Pain syndrome of moderate and mild intensity of various origins: headache; migraine; toothache; neuralgia; arthralgia and myalgia (pain in the muscles and joints); algodismenorrhea (pain during menstruation).

Dosage and administration: The drug is taken orally during or after a meal. Adults and adolescents from 15 years of age: 1 tablet every 4-6 hours. At the first signs of migraine, take 2 tablets. The average daily dose is 3-4 tablets per day, the maximum daily dose is 6 tablets per day. After taking 2 tablets, relief from headaches and other types of pain usually occurs quickly – after 15 minutes, with migraines, relief usually occurs after 30 minutes. In pain syndrome, the drug should not be taken for more than 5 days without consulting a doctor. For migraine, the drug should not be taken for more than 3 days without consulting a doctor.

Contraindications: hypersensitivity to any of the components in the composition of the drug; erosive and ulcerative lesions of the gastrointestinal tract in the acute phase; gastrointestinal bleeding; complete or incomplete combination of bronchial asthma, recurrent polypnosis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (including history); surgical interventions accompanied by bleeding; hemophilia; hemorrhagic diathesis; hypoprothrombinemia; severe arterial hypertension; portal hypertension; severe course of coronary artery disease; glaucoma; avitaminosis K; kidney failure; simultaneous use of other drugs containing paracetamol, acetylsalicylic acid or other non-steroidal anti-inflammatory drug; deficiency of glucose-6-phosphate dehydrogenase; pregnancy; lactation; increased excitability; sleep disorders; children under 15 years of age (risk of developing Reye’s syndrome in children with hyperthermia on the background of viral diseases). Use the drug with caution in case of gout, liver diseases, headaches associated with head trauma, taking anticoagulants, hypoglycemic agents, gout or arthritis, as well as while taking drugs containing acetylsalicylic acid or other analgesic and antipyretic components.

Precautionary measures: If after taking the drug the symptoms persist, worsen or new symptoms occur, you should immediately consult a doctor. When taking the drug at the recommended dose, the body receives as much caffeine as is contained in one cup of coffee, so you should reduce the consumption of caffeinated products during treatment with this drug in order to avoid the development of nervous excitement, irritability, insomnia and heart palpitations against the background of an overdose of caffeine. If an overdose is suspected, medical attention should be sought immediately, even if there are no symptoms. You should refrain from drinking alcohol while taking the drug due to an increased risk of liver damage and gastrointestinal bleeding. Since acetylsalicylic acid slows down blood clotting, the patient who is to undergo surgery should warn the doctor in advance about taking the drug. Acetylsalicylic acid in low doses reduces the excretion of uric acid, and therefore, in patients with a predisposition, the drug can provoke a gout attack.