Polyderm Topical Cream. 20g
Indications: The cream is used for various inflammatory skin diseases
Compound: Each 100 grams of cream contains:
Beclomethasone dipropionate anhydrous 0.025 mg
Miconazole nitrate 2.0 g
Neomycin sulfate 0.5 g
Chlorocresol 0.1 g
Auxiliary components: Cetyl alcohol, glyceryl monostearate, glycerol, methyl parahydroxybenzoate, propylene glycol, macron, cetostearyl, purified water.
Properties: Beclomethasone dipropionate: GCS for topical use. Beclomethasone in the form of dipropionate is a prodrug and has a weak tropism for glucocorticoid receptors. Under the action of esterases, it turns into an active metabolite – beclomethasone-17-monopropionate, which has a pronounced local anti-inflammatory effect by reducing the formation of chemotaxis substance (influence on delayed-type allergic reactions). By suppressing the production of arachidonic acid metabolites and reducing the release of inflammatory mediators from mast cells, it inhibits the development of an immediate type of allergic reaction.
Miconazole nitrate: Miconazole is an antifungal agent from the group of imidazole derivatives, active against most pathogenic fungi and yeasts. The mechanism of action is associated with a change in the permeability of cell membranes due to the suppression of ergosterol biosynthesis, changes in the lipid composition of membranes, and an inhibitory effect on the activity of oxidases and peroxidases. The accumulation of ergosterol precursors and toxic peroxides leads to the death of the fungal cell.
Neomycin sulfate: Aminoglycoside antibiotic. Violates protein synthesis, inhibiting the formation of a complex of transport and messenger RNA. At low concentrations, it has a bacteriostatic effect (due to disruption of protein synthesis in microbial cells), at high concentrations it has a bactericidal effect (it damages the cytoplasmic membranes of a microbial cell).
Chlorocresol: Antiseptic and disinfectant, chlorine derivative of phenol. Acts bactericidal. Chlorocresol is active against gram-positive and gram-negative bacteria, effective against fungi. It has little activity against bacterial spores.
Indications: The cream is used for various inflammatory skin diseases: – secondary bacterial infection. – fungal infection. – eczema, including atopic. – contact eczema. – stasis eczema. – children’s eczema. – seborrheic dermatitis. – neurodermatitis. – photosensitive dermatitis. – insect bites. – infected fungal infections. – secondarily infected rash. Dosage and administration: Apply externally in a thin layer 2 times a day.
Contraindications: Hypersensitivity to the components of the drug. Violation of the integrity of the skin, a large area of the lesion, weeping at the site of application, trophic ulcers; Simultaneous use with other oto- and nephrotoxic drugs. Pregnancy. Syphilis.
Precautionary measures: The courses of application of the cream should be limited, and occlusive dressings should not be used for severe eczema and on the face to avoid atrophic changes. Beclomethasone dipropionate should be used with caution in patients with severe circulatory disorders, since these patients have developed skin ulcers after the use of potent topical corticosteroids. Topical application of neomycin in patients with extensive skin lesions or eardrum perforations may result in deafness.
Side effects: Allergic reactions: itching, rash, hyperemia, swelling. Prolonged use of the cream can lead to contact allergies. Storage method: Store at a temperature not exceeding 25 degrees.