Description

Compound: Each tablet contains:

Trimethoprim 160 mg

Sulfamethoxazole 800 mg

Auxiliary components: potato starch, talc, magnesium stearate, polyvinyl alcohol.

Properties: Combined antibacterial drug, contains sulfamethoxazole and trimethoprim. Sulfamethoxazole, similar in structure to PABA, disrupts the synthesis of dihydrofolic acid in bacterial cells, preventing the incorporation of PABA into its molecule. Trimethoprim enhances the action of sulfamethoxazole, disrupting the reduction of dihydrofolic acid to tetrahydrofolic acid, the active form of folic acid responsible for protein metabolism and microbial cell division. It is a bactericidal drug with a wide spectrum of action. Active against the following microorganisms: Streptococcus spp. (hemolytic strains are more sensitive to penicillin), Staphylococcus spp., Streptococcus pneumoniae, Neisseria meningitidis, Neisseria gonorrhoeae, Escherichia coli (including enterotoxigenic strains), Salmonella spp. (including Salmonella typhi and Salmonella paratyphi), Vibrio cholerae, Bacillus anthracis, Haemophilus influenzae (including ampicillin-resistant strains), Listeria spp., Nocardia asteroides, Bordetella pertussis, Enterococcus faecalis, Klebsiella spp., Proteus spp., Pasteurella spp., Francisella tularensis , Brucella spp., Mycobacterium spp. (including Mycobacterium leprae), Citrobacter spp., Enterobacter spp., Legionella pneumopbila, Providencia, some species of Pseudomonas (except Pseudomonas aeruginosa), Serratia marcescens, Shigella spp., Yersinia spp., Morganella spp., Pneumocystis carinii, Chlamydia spp. (including Chlamydia trachomatis, Chlamydia psittaci); protozoa – Plasmodium spp., Toxoplasma gondii; Actinomyces israeli; pathogenic fungi – Coccidioides immitis, Histoplasma capsulatum; Leishmania spp. Resistant to the drug: Corynebacterium spp., Pseudomonas aeruginosa, Mycobacterium tuberculosis, Treponema spp., Leptospira spp., viruses. It inhibits the vital activity of Escherichia coli, which leads to a decrease in the synthesis of thiamine, riboflavin, nicotinic acid and other B vitamins in the intestine. The duration of the therapeutic action is 7 hours.

Indications: Treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the drug: – respiratory tract infections (including bronchitis, pneumonia, lung abscess, pleural empyema); – otitis, sinusitis; – infections of the genitourinary system (including pyelonephritis, urethritis, salpingitis, prostatitis); -gonorrhea; – infections of the gastrointestinal tract (including typhoid fever, paratyphoid fever, bacillary dysentery, cholera, diarrhea); – infections of the skin and soft tissues (including furunculosis, pyoderma).

Dosage and administration: The drug is taken orally after meals with a sufficient amount of liquid. The dose is set individually. For adults and children over 12 years of age, the drug is prescribed 960 mg 2 times / day, with long-term therapy – 480 mg 2 times / day. The duration of the course of treatment is from 5 to 14 days. In severe cases of the disease and / or chronic infections, it is possible to increase the single dose by 30-50%. With the duration of the course of therapy for more than 5 days and / or an increase in the dose of the drug, it is necessary to control the picture of peripheral blood; when pathological changes appear, folic acid should be prescribed at a dose of 5-10 mg / day.

Contraindications: -established diagnosis of damage to the liver parenchyma; – severe renal dysfunction in the absence of the ability to control the concentration of the drug in the blood plasma; – severe renal failure (CC less than 15 ml / min); – severe blood diseases (aplastic anemia, B12 deficiency anemia, agranulocytosis, leukopenia, megaloblastic anemia, anemia, hyperbilirubinemia in children associated with folic acid deficiency); – deficiency of glucose-6-phosphate dehydrogenase (risk of hemolysis); simultaneous use with dofetelide, paclitaxel and amiodarone; -simultaneous use with clozapine due to the ability of the latter to cause agranulocytosis; -pregnancy; -lactation; – children’s age up to 3 years (for this dosage form); – hypersensitivity to the components of the drug; hypersensitivity to co-trimoxazole, trimethoprim, sulfonamides. With caution, the drug is prescribed for folic acid deficiency in the body, bronchial asthma, and thyroid diseases.

Precautionary measures: The drug should be prescribed only in cases where the advantage of such combination therapy over other antibacterial monopreparations outweighs the possible risk. Since the sensitivity of bacteria to in vitro antibacterial drugs varies in different geographic areas and over time, local characteristics of bacterial susceptibility should be taken into account when choosing a drug. Hypersensitivity and allergic reactions At the first appearance of a skin rash or any other severe adverse reaction, the drug should be discontinued.