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Thyroxine 100mcg. 100 tablets

Thyroxine 100mcg. 100 tablets


Levothyroxine Sodium


Each tablet contains:

Levothyroxine sodium 100 mcg

Synthetic levorotatory isomer of thyroxine. After partial transformation into triiodothyronine (in the liver and kidneys) and transition into the cells of the body, it affects the development and growth of tissues, and metabolism. In small doses, it has an anabolic effect on protein and fat metabolism. In medium doses, it stimulates growth and development, increases the need for oxygen in tissues, stimulates the metabolism of proteins, fats and carbohydrates, increases the functional activity of the cardiovascular system and the central nervous system. In large doses, it inhibits the production of thyrotropin-releasing hormone of the hypothalamus and thyroid-stimulating hormone of the pituitary gland. The therapeutic effect is observed after 7-12 days, during the same time the effect persists after the drug is discontinued. The clinical effect in hypothyroidism appears after 3-5 days. Diffuse goiter decreases or disappears within 3-6 months.

Hypothyroidism; euthyroid goiter; as a replacement therapy and for the prevention of recurrence of goiter after resection of the thyroid gland; thyroid cancer (after surgical treatment); diffuse toxic goiter: after reaching the euthyroid state with antithyroid drugs (as a combination or monotherapy); as a diagnostic tool in the thyroid suppression test.

Dosage and administration:
The method of application and dosing regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed. Set individually depending on the indications. Apply at a dose of 12.5-200 mcg 1 time / day for 20-30 minutes before meals. When conducting a differential diagnostic test of thyroid suppression – once at a dose of 3 mg or for 2 weeks, 200 mcg 1 time / day.

Hypersensitivity to levothyroxine sodium; untreated thyrotoxicosis; acute myocardial infarction, acute myocarditis; untreated adrenal insufficiency. With caution: in diseases of the cardiovascular system – coronary artery disease (atherosclerosis, angina pectoris, history of myocardial infarction), arterial hypertension, arrhythmias; with diabetes mellitus, severe long-term hypothyroidism, malabsorption syndrome (dose adjustment may be required).

Precautionary measures:
Use with extreme caution in patients with cardiovascular diseases (including coronary artery disease, heart failure, arterial hypertension). In such cases, levothyroxine sodium should be used at a low initial dose, increasing it slowly and at long intervals. In hypothyroidism due to damage to the pituitary gland, it is necessary to find out whether there is a simultaneous insufficiency of the adrenal cortex. In this case, GCS replacement therapy should be started before the start of treatment of hypothyroidism with thyroid hormones in order to avoid the development of acute adrenal insufficiency. In elderly patients and with a long course of hypothyroidism, treatment should be started gradually.

Use with caution in diabetes and diabetes insipidus. When conducting a differential diagnostic test of thyroid suppression, patients with diabetes mellitus are advised to increase the doses of antidiabetic agents. In some cases, thyroid hormones can cause or aggravate the previous myasthenic syndrome.

Side effects:
Symptoms of hyperthyroidism: possible (when used in high doses, including when the dose is increased too quickly at the beginning of the course of treatment) tachycardia, palpitations, arrhythmias, angina attacks, headache, nervousness, tremor, sleep disturbances, a feeling of internal anxiety, muscular weakness and cramps, weight loss, diarrhea, menstrual irregularities, vomiting.

Storage method:
At a temperature not higher than 25 degrees. In a dry place protected from the sun.


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