Description

Composition: Each sachet contains:

Piperazine citrate 0.1408 g (up to 0.128 g piperazine hydrate).

Colchicine 0.3 mg.

Atropine sulfate 0.128 mg.

Auxiliary components: sodium bicarbonate, anhydrous citric acid, tartaric acid, P.V.P, lemon oil, sucrose.

Properties: Piperazine has been known for many years as an effective drug in the treatment of gout and urinary tract lithiasis. It increases the solubility of urates in the urine and has low toxicity. Colchicine gives rapid pain relief in acute attacks of gout, and the drug is specific to this condition, so it can be used as a diagnostic tool for gout and gouty arthritis. Colchicine has anti-inflammatory properties. Although it is very effective in treating acute gouty arthritis, it is not effective in other types of pain. It is not an analgesic and does not affect the clearance of uric acid. Instead, colchicine binds to neutrophil microtubule proteins. This binding, in turn, inhibits the migration of neutrophils to the site of inflammation, thereby interfering with the inflammatory response to urate crystal deposition. Atropine sulfate is added to relieve spasm of the urinary tract.

Indications: Acute and chronic gout. Gouty arthritis. For the prevention of urolithiasis.

Dosage and administration: For an acute attack: dissolve 1 sachet in half a glass of water and take 6 times a day. To prevent an acute attack: dissolve 2 sachets in a glass of water and take 2 times a day. As a preventive measure: dissolve 2 sachets in a glass of water and take once a day.

Contraindications: Known hypersensitivity to any of the components of the drug. Blood dyscrasia. Acute dehydration, anuria or hyperkalemia.

Precautionary measures: Use with caution in patients with serious disorders of the gastrointestinal tract, kidneys, liver and cardiovascular system. The drug should not be taken in children, geriatrics, debilitated patients and lactating women.

Side effects: Occasionally, nausea, vomiting, abdominal pain, and diarrhea may occur.

Storage method: At a temperature not higher than 25 degrees. In a dry place.