Description

Composition:

Each gram of cream contains 1.0% terbinafine hydrochloride.

Properties:

Antifungal drug for topical use with a broad spectrum of antifungal activity. Even in small concentrations, terbinafine has fungicidal activity against dermatophytes (Trychophyton rubrum, T.mentagrophytes, T.verrucosum, T.violaceum, T.tonsurans, Microsporum canis, Epidermophyton floccosum), molds (mainly C. (Pityrosporum orbiculare). Activity against yeast fungi, depending on their species, can be fungicidal or fungistatic.

Terbinafine specifically alters the early stage of sterol biosynthesis that occurs in fungi. This leads to ergosterol deficiency and intracellular accumulation of squalene, which causes the death of the fungal cell. The action of terbinafine is carried out by inhibiting the squalene epoxidase enzyme located on the fungal cell membrane.

Terbinafine does not affect the cytochrome P450 system in humans and, accordingly, the metabolism of hormones or other drugs. preparations.

Indications:

– prevention and treatment of fungus, fungal infections of the skin, including athlete’s foot (“fungus” of the foot), inguinal epidermophytosis (tinea cruris), fungal lesions of the smooth skin of the body (tinea corporis), caused by dermatophytes such as Trichophyton (including T. rubrum, T. mentagrophytes, T. verrucosum, T.violaceum), Microsporum canis and Epidermophyton floccosum;

– yeast infections of the skin, mainly those caused by the genus Candida (for example, Candida albicans), in particular diaper rash;

– multi-colored lichen (Pityriasis versicolor), caused by Pityrosporum orbiculare (also known as Malassezia furfur).

Method of application and dosage:

Adults and children from 12 years of age:

Before applying the cream, the affected areas must be cleaned and dried. The cream is applied once or twice a day. a day, apply a thin layer to the affected skin and adjacent areas and rub in lightly. In infections accompanied by diaper rash (under the mammary glands, in the interdigital spaces, between the buttocks, in the groin area), the places of application of the cream can be covered with gauze, especially at night.

Average duration of treatment: dermatomycosis of the trunk, lower legs – 1 week 1 time per day; dermatomycosis of the feet – 1 week 1 time per day; candidiasis of the skin – 1-2 weeks 1 or 2 times per day; lichen varicolor: 2 weeks 1 or 2 times per day.

Contraindications:

-hypersensitivity to terbinafine or any of the inactive ingredients included in the preparation.

With caution: hepatic and/or renal failure, alcoholism, suppression of bone marrow hematopoiesis, tumors, metabolic diseases, occlusive vascular diseases limbs, children’s age up to 12 years (lack of sufficient clinical experience).

Precautions:

A decrease in the severity of clinical manifestations is usually observed in the first days of treatment. In case of irregular treatment or premature termination, there is a risk of recurrence of infection.

Terbin cream is intended for external use only. It should be avoided to get it into the eyes, as it can cause irritation. If the drug accidentally gets into the eyes, they should be immediately rinsed with running water, and in case of persistent irritation, you should consult a doctor.

If allergic reactions develop, the drug should be discontinued.

Side effects:

Redness, itching or burning may appear at the site of application of the drug. Allergic reactions.

Storage method:

At a temperature not exceeding 25 degrees. In a dry place.