Description

Compound:

Each capsule contains:

ursodeoxycholic acid 250 mg

silymarin 140 mg

Properties: Hepatoprotector. Ursodeoxycholic acid is a bile acid. Reduces the content of cholesterol in bile mainly by dispersing cholesterol and forming a liquid-crystalline phase. It has an effect on the enterohepatic circulation of bile salts, reducing the reabsorption in the intestine of endogenous more hydrophobic and potentially toxic compounds. In vitro studies have shown that ursodeoxycholic acid has a direct hepatoprotective effect and reduces the hepatotoxicity of hydrophobic bile salts. It has an effect on immunological reactions, reducing the pathological expression of class I HLA antigens on hepatocytes and suppressing the production of cytokines and interleukins. Ursodeoxycholic acid reduces the lithogenic index of bile by increasing the content of bile acids in it. Promotes partial or complete dissolution of cholesterol gallstones when administered orally. It has a choleretic effect. Silymarin: Belongs to the group of hepatoprotectors. Prevents the destruction of cell membranes, due to the ability to inhibit lipid peroxidation. Stimulates the synthesis of protein and phospholipids in damaged hepatocytes, as a result of which cell membranes are stabilized, loss of cell components is prevented. Prevents the penetration into the cell of some hepatotoxic substances (in particular, the poisons of the fungus pale toadstool). Silibinin is the main component of silymarin, the biologically active substance of milk thistle fruits.

Indications: Cholesterol gallstones in the gallbladder and common bile duct in patients where surgical or endoscopic treatment is not possible. Cholesterol stones of the gallbladder and common bile duct with a diameter of not more than 1.5-2 cm after extracorporeal lithotripsy or mechanical lithotripsy. Primary biliary cirrhosis (before the formation of advanced fibrosis and cirrhotic transformation of the liver). Chronic active hepatitis with cholestatic syndrome. Acute hepatitis, cystic fibrosis of the liver, congenital atresia of the bile duct. Biliary reflux esophagitis and gastritis. Biliary dyspeptic syndrome in cholecystopathy and biliary dyskinesia. Prevention and treatment of cholestatic syndrome caused by the use of hormonal contraceptives. To normalize liver function in patients receiving cytostatic therapy, as well as in patients with alcoholic liver damage. Transplantation of the liver and other organs (auxiliary treatment).

Dosage and administration: The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed. Set individually. Usually used at a dose of up to 10 mg / kg / day. The daily dose is taken once in the evening. The duration of treatment depends on the indications.

Contraindications: Hypersensitivity to silymarin. Acute inflammatory diseases of the gallbladder and biliary tract, cirrhosis of the liver in the stage of vascular and parenchymal decompensation and / or severe activity, UC, Crohn’s disease, severe renal dysfunction, hypersensitivity to ursodeoxycholic acid.

Precautionary measures: For successful litholysis with ursodeoxycholic acid, the following conditions must be met: the stones must be pure cholesterol, i.e. do not give a shadow on the radiograph; the size of the stones should not exceed 15-20 mm; the gallbladder must fully retain its function; the gallbladder should be filled with stones no more than half; the patency of the cystic duct must be maintained; the common bile duct should be free of stones. When using ursodeoxycholic acid to dissolve gallstones in the first 3 months of treatment, it is necessary to determine the activity of liver transaminases every 4 weeks. In the future, these studies can be carried out with an interval of 3 months. To monitor the effectiveness of treatment, it is recommended to conduct x-ray and ultrasound examination of the biliary tract every 6 months. To prevent recurrence of cholelithiasis, treatment must be continued for several more months after the dissolution of gallstones.

Side effects: Perhaps: a transient increase in liver transaminase activity, pruritus, allergic reactions. Rarely: diarrhea, calcification of gallstones. Rarely: laxative effect, allergic reactions.

Storage method: At a temperature no higher than 30 degrees.